Final answer:
Spanish settlements in New Spain had a largely negative impact on Native Americans due to forced labor, disease, and cultural displacement, overshadowing occasional positive interactions.
Step-by-step explanation:
The Spanish settlements had negative effects on the lives of Native Americans in New Spain. Forced labor under the encomienda system, the spread of diseases such as smallpox, and cultural displacement deeply impacted Native American societies. Although there were instances of cultural exchange and cooperation, such as Native Americans becoming vaqueros, the overwhelming effect was exploitative. Despite some native resistance and the preservation of native languages in parts of Central and South America, the toll of colonization was devastating, with many native peoples suffering from disease, forced conversion, and loss of autonomy.