Final answer:
The indication of a hemolytic transfusion reaction during a blood transfusion by a nurse is the presence of fever and chills, which aligns with the body's response to incompatible RBCs.
Step-by-step explanation:
A nurse administering packed red blood cells (RBCs) must be vigilant for signs of a hemolytic transfusion reaction (HTR). One of the primary symptoms of an HTR includes fever and chills, related to the body's inflammatory response to incompatible blood, which signifies the immune system is attacking the transfused blood cells.
This reaction can lead to additional symptoms like pruritus (itching), urticaria (hives), dyspnea, hemoglobinuria, and hypotension. Out of the options provided, the symptom that indicates a hemolytic transfusion reaction is: