Final answer:
The correct instruction for Sam regarding NSAID usage is to start with the lowest effective dose to manage pain, as long-term use can cause gastrointestinal issues like ulcers and bleeding.
Step-by-step explanation:
When teaching Sam about the use of NSAIDs to manage his low back strain, the most appropriate statement is option A: "You should start with the lowest dose that is effective in managing your pain because long-term use of NSAIDs can result in gastrointestinal (GI) disorders such as ulcers and hemorrhage." This is important because NSAIDs can cause stomach bleeding, especially in individuals with certain risk factors, and can also lead to kidney damage. NSAIDs, like aspirin, ibuprofen, and naproxen, work by inhibiting the conversion of arachidonic acid into prostaglandins, which cause inflammation and pain.
Starting with the lowest dose reduces the risk of these adverse effects and recognizes that while these drugs are effective for low-to-moderate intensity pain, they need to be used with caution. Moreover, NSAIDs should not be taken on an empty stomach to avoid GI discomfort, contradicting option D. In addition, option B is incorrect because tolerance is not a common issue with NSAIDs, and option C is misleading because the maximum dose should not be taken initially but reached gradually if needed and under medical supervision to manage pain effectively and safely.