Final answer:
The most direct way to break the cycle of infection is to prevent transmission from the Host to the environment.
Step-by-step explanation:
The most direct way to break the cycle of infection is to prevent transmission from the Host to the environment. This can be achieved by practicing good hygiene, such as washing hands regularly, covering the mouth and nose when coughing or sneezing, and properly disposing of contaminated items. By preventing the transmission of pathogens from the host to the environment, the spread of infection can be minimized.