Final answer:
The weak bonds involved in Rho-independent termination occur when RNA polymerase transcribes a region rich in A-T nucleotides, leading to the formation of a hairpin loop in the mRNA that stalling the polymerase and inducing its release from the DNA template.
Step-by-step explanation:
The Rho-independent termination is a process in prokaryotic transcription where the RNA polymerase encounters a sequence on the DNA template that causes it to stall and terminate transcription. This occurs when the polymerase transcribes a region rich in C-G nucleotides, leading to the formation of a hairpin loop structure in the nascent mRNA.
This loop causes the polymerase to stall as it begins to transcribe a region rich in A-T nucleotides, where the mRNA forms a weak interaction with the template DNA. This weak bond and the stalled polymerase induce the dissociation of the RNA polymerase from the DNA template and the release of the newly synthesized mRNA.