Final answer:
The major CNS danger signals in the neonate include temperature instability, apnea, bradycardia, hypotension, difficulty feeding, irritability, and limpness. Late-onset disease symptoms may include seizures, bulging fontanel, stiff neck, hemiparesis, and opisthotonos.
Step-by-step explanation:
The major CNS (central nervous system) danger signals that occur in the neonate include temperature instability, apnea (cessation of breathing), bradycardia (slow heart rate), hypotension (low blood pressure), difficulty feeding, irritability, and limpness. These are signs and symptoms of early onset disease in a newborn. Late-onset disease symptoms may include seizures, bulging fontanel (soft spot), stiff neck, hemiparesis (weakness on one side of the body), and opisthotonos (rigid body with arched back and head thrown backward).