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In normal vs. Alzheimer's processing, how many amino acid (aa) APP fragments are typically found?

a) 10-20 aa
b) 30-40 aa
c) 50-60 aa
d) 70-80 aa

User AdRock
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1 Answer

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Final answer:

Enzymatic cleavage of APP typically produces extracellular Ab peptides of 39-43 amino acids in length, which are digested under normal conditions but accumulate and form plaques in Alzheimer's disease.

Step-by-step explanation:

In the comparison of normal vs. Alzheimer's processing, enzymatic cleavage of the amyloid precursor protein (APP) typically produces extracellular amyloid beta (Ab) peptides consisting of 39-43 amino acids. Normally, these Ab peptides are further digested to prevent accumulation. However, in Alzheimer's disease, these peptides can accumulate and form the characteristic extracellular amyloid plaques.

User Pallavi
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