Final answer:
The first wife of King Henry VIII of England, who was the daughter of Ferdinand and Isabella, was Catherine of Aragon.
Step-by-step explanation:
The Spanish-born woman who was the daughter of Ferdinand and Isabella and the first wife of England's King Henry VIII was Catherine of Aragon.
Despite having one living child, a daughter named Mary, Henry desired a son to secure the succession of the Tudor monarchy. When Catherine failed to provide him with a male heir, Henry sought an annulment of their marriage.
When the pope refused his request, Henry broke away from the authority of the Catholic Church and established the Church of England, allowing him to annul his own marriage and marry Anne Boleyn.