Final answer:
During the French Wars of Religion, the ruling family of France was the House of Valois, into which Catherine de Medici married when she became queen.
Step-by-step explanation:
During the French Wars of Religion, Catherine de Medici, an Italian noblewoman who married King Henry II of France, was a member of the House of Valois. This royal family ruled France at the time. Although Catherine was not a member of the Valois family by birth, her marriage to Henry II brought her into this French royal house. The House of Valois faced significant challenges during the Wars of Religion, a period marked by intense religious and civil conflict, culminating in events like the Saint Bartholomew's Day Massacre in 1572. These conflicts were part of the broader struggle between Catholics and Protestants in France during the 16th century. The correct answer to which the ruling family of France was during the French Wars of Religion is B) House of Valois.