Final answer:
Respiratory distress is an early manifestation of a fat embolism in a patient with a comminuted fracture of the femur, as it signals hypoxemia and the onset of potential respiratory complications.
Step-by-step explanation:
The nurse should identify respiratory distress as an early manifestation of a fat embolism when assessing a client with a comminuted fracture of the femur. Fat embolism syndrome (FES) can occur when fat droplets enter the bloodstream following a fracture, especially of long bones such as the femur. Early signs of FES include hypoxemia, tachypnea, and dyspnea, which are indicators of respiratory distress. This can lead to further complications, such as respiratory failure, if not recognized and managed promptly. While other manifestations can eventually occur, such as hypotension, tachycardia, fever, and neurological changes, respiratory distress often presents early in the course of FES.