Final answer:
Urticaria (hives) and hypotension are signs of an anaphylactic reaction after the administration of IV penicillin G. Anaphylaxis may lead to life-threatening symptoms and requires immediate medical attention.
Step-by-step explanation:
When assessing a client following the administration of IV penicillin G for signs of an anaphylactic reaction, the nurse should look for indications such as hypotension, changes in heart rate, respiratory distress, and severe swelling of the throat. Anaphylaxis is a systemic and potentially life-threatening type I hypersensitivity reaction characterized by symptoms like plummeting blood pressure (anaphylactic shock), difficulty breathing, and urticaria (hives). Of the options given, urticaria (D) is a sign of anaphylactic reaction, accompanied by hypotension (B), which is more indicative of anaphylaxis than bradycardia (A) or hyperthermia (C).