Final answer:
The nurse should instruct the client to discard cloudy solutions, use a smaller gauge needle, follow the prescribed schedule (typically once weekly, not alternate days), and avoid shaking the reconstituted solution of etanercept.
Step-by-step explanation:
When instructing a client on the proper self-administration of etanercept for the treatment of rheumatoid arthritis, several key points need to be emphasized. First, it is crucial to instruct the client to discard any solutions that are cloudy or have particulates, as this can indicate contamination or a change in the medication's efficacy. Additionally, recommending the use of a smaller gauge needle such as a 25 or 27-gauge needle instead of a 21-gauge needle may minimize discomfort during injection. Etanercept should not be administered on alternative days; instead, it should be given according to the prescriber's instructions, which often involve once-weekly injections. Finally, the client should be cautioned against shaking the reconstituted solution as this can damage the medication. Gentle swirling is recommended if mixing is necessary.