Final answer:
In the context of major depressive disorder, a nurse should recognize poor appetite as a clinical manifestation of the condition, while increased energy levels, elevated mood, and hyperactivity are not consistent with major depression.
The correct answer is D.
Step-by-step explanation:
The nurse should identify poor appetite as a clinical manifestation of major depressive disorder. Major depression is associated with a range of symptoms, including intense sadness and despair, mental slowing, pessimistic worry, physical changes like weight loss, decreased libido, and disruptions in sleep and hormonal patterns. Elevated mood, increased energy levels, and hyperactivity are not typically associated with major depressive disorder and would more likely be seen in conditions such as bipolar disorder during a manic episode.