Final answer:
The nurse should choose option C, which communicates personal discomfort about the coworker's inappropriate behavior and helps set clear boundaries.
Step-by-step explanation:
The appropriate response for the nurse in the situation described would be C. "Speaking to me like that makes me uncomfortable." This response directly addresses the coworker's inappropriate behavior by communicating personal feelings about it rather than diverting the conversation (A), dismissing the relevance of the comment (B), or raising unrelated issues such as voice volume (D). Communicating discomfort can help set boundaries and can be an effective way to halt further similar interactions. Additionally, expressing feelings can sometimes be less confrontational and invite the other person to understand and rectify their behavior without escalating the situation.