Final answer:
The Frank family moved from Germany to the Netherlands when they left Germany in late 1933, seeking refuge from the Nazi regime.
Step-by-step explanation:
When the Frank family first left Germany, they moved to the Netherlands, which they hoped would be a safe location due to its neutral position in World War I. The German-Jewish Frank family was specifically seeking refuge from the Nazi regime and settled in the Netherlands in late 1933. Unfortunately, the German occupation of the Netherlands in 1940 marked the beginning of a perilous period for the Franks and many other Jewish families, leading to the eventual hiding of the Frank family in an annex, famously documented by Anne Frank in her diary.