Final answer:
Eukaryotic DNA replication is significantly slower than prokaryotic replication, and it involves multiple origins of replication, unlike the single origin found in prokaryotes.
Step-by-step explanation:
One key difference between eukaryotic DNA replication and prokaryotic DNA replication is the speed and complexity of the process. Eukaryotic replication is approximately ten times slower, at a rate of about 100 nucleotides per second, compared to prokaryotic replication which can incorporate roughly 1000 nucleotides per second. Additionally, eukaryotes utilize multiple origins of replication within their larger and more complex genomes, while prokaryotes typically have a single origin of replication for their smaller and simpler genomes.