Final answer:
Hayden most likely lives in a region close to the Mississippi river valley which has a high occurrence of histoplasmosis cases if that's what is referred to by 'hot spots'.
Step-by-step explanation:
If Hayden lives in a part of the United States that has a high occurrence of hot spots, and given the options provided, none of the cities (Los Angeles, Boston, Miami, Detroit) relate directly to the occurrence of natural hotspots like Yellowstone.
However, if we are discussing histoplasmosis, as referenced, then Hayden most likely lives in the Mississippi river valley, which is not specifically listed but closest to the information provided regarding the high occurrence of histoplasmosis cases in the United States.