Final answer:
Rosalind Franklin's upbringing remained constant throughout her career, and while she did not undergo a significant religious change, she grew more distant from religious affiliations, consistent with option D) in the question.
Step-by-step explanation:
The significant change that occurred in Rosalind Franklin's upbringing and religion during her scientific career is best represented by option D) Her upbringing remained constant, but she distanced herself from any religious affiliations. Franklin, who began her career with a focus on the physical chemistry of coal and carbon, later shifted her expertise to the study of biological systems, particularly DNA structure.
Her meticulous work in X-ray diffraction provided essential information for the discovery of DNA's double helix structure. Though the question implies that there might have been a religious shift during her career as a scientist, there is no substantial evidence indicating a significant change in her personal religious beliefs. In fact, based on the historical context provided, it is understood that significant changes in religious affiliation are uncommon and often occur due to life-changing events, which were not prominently featured in Franklin's biography. Consequently, the available evidence doesn't support a major religious transition during Franklin's life as a scientist.