Final answer:
Shakespeare's 'Venus and Adonis' was the most widely printed work of his career, surpassing the individual quartos of his plays during his lifetime, with 'Venus and Adonis' published in 1593.
Step-by-step explanation:
The most widely printed work of Shakespeare's career was c. Venus and Adonis. This long poem was published in 1593 and outpaced the printing of Shakespeare's plays during his lifetime.
Despite Shakespeare's profound influence on English literature and the theatre as a writer, actor, and producer, none of his plays were published in book form during his life; there were only individual quartos. It is evident from his diverse roles in the London theater that he was very involved in every aspect of production.
Shakespeare's popularity greatly increased posthumously with the publication of the First Folio in 1623, which collected his dramatic works.
The most widely printed work of Shakespeare's career was Venus and Adonis, a long poem published in 1593. While Shakespeare is best known for his plays, this poem was a popular work during his lifetime. It is often considered his first literary success and showcases his skillful use of language.