Final answer:
One difference between birds and mammals is that birds have nearly hollow bones and a unidirectional system for breathing, providing efficient oxygen transport necessary for flight.
Step-by-step explanation:
The difference between birds and mammals lies in their respective respiratory systems and skeletal structures. Birds have nearly hollow bones that are filled with air and they possess a unique respiratory system. While both birds and mammals have lungs for gas exchange, birds breathe through a unidirectional system, where air flows consistently and only in one direction through their lungs, unlike the bidirectional system in mammals. This adaptation provides birds with a more efficient means of oxygen transport to cells, essential for their high-energy demands of flight.