Final answer:
The Middle Colonies, encompassing New York, New Jersey, Pennsylvania, and Delaware, were known for their friendly relations with Native American tribes like the Delaware and Iroquois.
Step-by-step explanation:
The colonial region where colonists enjoyed friendly relations with the Delaware, Iroquois, and other native tribes was the Middle Colonies. This included areas that became New York, New Jersey, Pennsylvania, and Delaware. These colonies experienced higher levels of ethnic and religious diversity, which also translated into pragmatic, accommodative, and tolerant approaches in their relations with various Native American tribes. In particular, during the late seventeenth and early eighteenth centuries, colonial and tribal leaders encouraged their people to respect treaty agreements, leading to over fifty years of harmony.