Final answer:
The Treaty of Greenville marked the end of conflict between the U.S. and Native Americans, advancing U.S. interests by promoting territorial integrity and allowing for westward expansion.
Step-by-step explanation:
The statement that BEST explains how the Treaty of Greenville advanced U.S. interests is:
B. It marked the end of conflict between the U.S. and Native Americans.
The Treaty of Greenville, signed in 1795, effectively ended the Northwest Indian War between the United States and various Native American tribes. This treaty ceded Indian lands in the Ohio Valley to the United States and established a boundary beyond which settlers were not allowed to encroach. By ending the conflict and establishing a peaceful settlement, the treaty advanced U.S. interests by promoting territorial integrity and allowing for the westward expansion of pioneer settlement.