Final answer:
As a cell increases in size, its surface area-to-volume ratio decreases.
Step-by-step explanation:
As a cell increases in size, its surface area-to-volume ratio decreases. This means that as the cell gets larger, the amount of surface area available relative to its volume decreases. This is because the surface area increases as the square of the radius, while the volume increases as the cube of the radius. If a cell grows too large, it may not have sufficient surface area to support the rate of diffusion required for the increased volume, leading to cell division or death.