Final answer:
The Choctaw, Chickasaw, and Natchez tribes were among the largest Native American tribes in Mississippi when Europeans arrived.
Step-by-step explanation:
The three Native American tribes that were among the largest in Mississippi when Europeans arrived were the Choctaw, Chickasaw, and Natchez. These tribes had significant populations and established settlements in the region.
The Choctaw Nation, for example, signed multiple treaties with the U.S. government, ceding millions of acres of land in exchange for territory in present-day Oklahoma. The Chickasaw Nation also played a prominent role in the region, and the Natchez were known for their large cities and mound-building culture.
These tribes, along with others like the Creek and Cherokee, faced forced removal as a result of the Indian Removal Act, which led to the tragic journey known as the Trail of Tears.