Final answer:
Net de novo lipogenesis would be greatest during the last few days of a week of excessive carbohydrate intake after glycogen stores are filled, and the body begins to convert excess glucose to fat.
Step-by-step explanation:
The question concerns the timing of net de novo lipogenesis, which is the metabolic process of converting excess carbohydrates into fatty acids and subsequently triglycerides, which are stored in adipose tissue. In a scenario where an individual overconsumes carbohydrates consistently over a week, the body's initial response is to replenish glycogen stores in both liver and muscle tissue. Once these stores are saturated, any additional carbohydrates will be converted into fat. This process is more likely to occur at a greater rate during the last few days of continuous overconsumption, because glycogen stores would be filled in the initial days, leaving the excess carbohydrates to be converted into fat as the week progresses.
Thus, net de novo lipogenesis would be greatest during the last few days of overfeeding when glycogen stores are already replenished and the body resorts to converting the extra glucose into fatty acids for long-term storage as triglycerides in adipose tissues.