Question

As we know integumentary system or skin is the first line of defense. This system protects the human body from the environmental changes. Skin is made up three major layers: epidermis, dermis and hypodermis. Skin can be damaged by uv radiation or by burns that can be due to chemical, electrical and or by intense heat. Burns kills the cells in the affected areas. The most concern in severe burns is loss of fluids that leads to dehydration and electrolyte imbalance. The percentage of body surface burned is estimated by rule of nines. Third-degree burns leaves no dermal tissue to regenerate, therefore it requires skin grafts and or artificial skin. Explain in what cases different types of skin grafting and or artificial skin will be used by medical team. Define different type of skin grafting and artificial skin.

Answer 1

Severe burns may require different types of skin grafting or artificial skin, such as autografts, allografts, and skin substitutes, to promote healing and replace damaged tissue. Autografts use the patient's own skin, while allografts use skin from other humans, and artificial skin products like Integra and Biobrane act as temporary protective coverings.

Step-by-step explanation:

Different Types of Skin Grafting and Artificial Skin

In cases of severe burns, different types of skin grafting and artificial skin might be used to help the healing process and repair damaged skin. Skin grafts are divided into two major categories: autografts and allografts. Autografts involve the transplantation of the patient's own skin from an unaffected area to the burned area. Allografts, also known as homografts, are made from the skin of another human (usually a cadaver). When large areas of the body are burned, and there is not enough healthy skin to harvest for autografts, artificial skin or skin substitutes may be used temporarily to cover and protect the body while it heals.

Artificial skin products, like Integra and Biobrane, are designed to mimic the functions of normal human skin. They are often used as a temporary covering, providing protection from infection and aiding in fluid retention. Once the wound bed is stabilized or when sufficient autografts become available, these temporary coverings are replaced by autografts for permanent closure. In the most severe cases where large portions of the dermis are lost and cannot regenerate, more advanced treatments such as cultured epidermal autografts (CEAs) or dermal regeneration templates might be employed. These involve growing skin cells in a lab or using a scaffold that allows the patient's cells to repopulate, creating a new dermal layer.