Question

Which of the following has the correct sequence of the pathophysiology of asthma?

A. Release potent proinflammatory mediators.
B. Activation of the inflammatory cascade.
C. Exposure to allergens or irritants
D. Bronchoconstriction of airways and mucus production.
1. C−>A−>B−>D
2. A−>B−>C−>D
3. C−>B−>A−>D
4. D−>B−>A−>C

Answer 1

The correct sequence of asthma pathophysiology starts with exposure to allergens, followed by activation of the inflammatory cascade, release of inflammatory mediators, and culminates in airway bronchoconstriction and mucus production. The accurate sequence is C->B->A->D.

Step-by-step explanation:

Understanding Asthma Pathophysiology

The correct sequence of the pathophysiology of asthma is as follows: first, there is an exposure to allergens or irritants. This exposure triggers the activation of the inflammatory cascade within the airways. During this process, various potent proinflammatory mediators are released, which include cytokines and histamines from mast cells. Finally, these mediators lead to bronchoconstriction of the airways and excessive production of mucus, which are key features in the clinical presentation of asthma. Considering these steps, the correct sequence from the options provided is exposure to allergens or irritants (C), activation of the inflammatory cascade (B), the release of potent proinflammatory mediators (A), followed by bronchoconstriction and mucus production (D).

Therefore, the correct sequence is 3. C→B→A→D.