Final answer:
Mesopotamia had a significant impact on ancient civilizations through the invention of the wheel, construction of irrigation canals, and the development of a written language. This led to the growth of cities, the development of centralized government and law codes, and the introduction of social stratification, slavery, and organized warfare.
Step-by-step explanation:
Mesopotamia, also known as the Cradle of Civilization, had a significant impact on ancient civilizations. Three causes of its impact were the invention of the wheel, the construction of irrigation canals, and the development of a written language called Cuneiform. These causes led to three effects: the growth of cities, the development of centralized government and law codes, and the introduction of social stratification, slavery, and organized warfare.