Final answer:
Christina Koch's record spaceflight resulted in decreased bone density due to prolonged weightlessness. Mechanical stress stimulates osteoblasts to produce bone matrix, which consists of mineral salts and calcium carbonate crystals. Giving astronauts calcitonin can help slow bone resorption by osteoclasts.
Step-by-step explanation:
Christina Koch's extended period in space caused a decrease in bone density. To build bone tissue, osteoblastic activity, a process that builds bone mass, occurs because of mechanical stress which leads to the secretion of bone matrix made up of mineral salts and calcium carbonate crystals. One potential therapy to alleviate bone loss in astronauts is to give them calcitonin, a hormone naturally produced by the thyroid gland that will slow the rate of osteoclast activity that resorbs bone.