Question

What can we say about the localization of insulin and of glucose transporters within their storage vesicles? a) Tramporters are in the lumen and insulin is in the veside membone b) Both are in the lumen c) Both are in the membrane Imulin is in the d) lumen and tranporten are in the membrane.

Answer 1

Insulin is stored within the lumen of vesicles, whereas glucose transporters are embedded in the vesicle membrane. Upon insulin binding to cell receptors, GLUT4 transporters in the vesicle membranes help facilitate glucose uptake into the cell.

Step-by-step explanation:

In regard to the localization of insulin and of glucose transporters within their storage vesicles, insulin is stored within the lumen of these vesicles, while glucose transporters, notably GLUT4, are embedded in the membrane of the vesicles. When insulin binds to its receptor on the plasma membrane, a cascade of events leads to the fusion of GLUT4-containing vesicles with the plasma membrane. This fusion facilitates the movement of glucose into the cell, helping to regulate blood sugar levels. Secreted peptides, such as insulin, are stored within vesicles and are released in response to specific stimuli like elevated blood glucose levels. The glucose transporters, such as GLUT4, help in the uptake of glucose by the cells.