Final answer:
The challenges confronted by the colonists at Cape Cod were difficult weather conditions, lack of proper attire, and scarcity of food supplies.
Step-by-step explanation:
The challenges that confronted the colonists when they arrived at Cape Cod were the difficult weather conditions and the lack of resources. In the winter of 1607, the colonists suffered from sweltering summer heat followed by a cold, damp chill. They were not properly attired and felt as if they would never be warm again. Additionally, the colonists were not well equipped with supplies, and their food stores spoiled due to the heat. This left them short on supplies and desperately in need of new sources of food.