Final answer:
The Grand Canyon and Las Vegas are approximately 270 miles apart.
Step-by-step explanation:
To find the actual distance between the Grand Canyon and Las Vegas, we need to use the given scale: 1 inch = 22.5 miles. Since the two places are 12 inches apart on the map, we can multiply 12 by the scale to find the actual distance.
12 inches * 22.5 miles/inch = 270 miles
Therefore, the Grand Canyon and Las Vegas are approximately 270 miles apart.