Final answer:
DNA polymerase is not directly involved in DNA supercoiling.
Step-by-step explanation:
DNA supercoiling is the twisting or winding of the DNA molecule that helps to compact it within the cell. The process of supercoiling involves enzymes called topoisomerases, which help to relieve the torsional strain caused by the twisting of the DNA strands. There are two types of topoisomerases involved in DNA supercoiling: type I and type II.
The correct answer to this question is D. DNA polymerase. DNA polymerase is an enzyme responsible for synthesizing new DNA strands during replication, but it is not directly involved in the process of DNA supercoiling.