Final answer:
True, systemic administration of a drug means delivering it through the blood circulation to achieve its intended action throughout the body. This is often done via IV or IM injections, especially when oral administration isn't effective or possible.
Step-by-step explanation:
True. Systemic administration refers to the method of administering a drug so that it reaches its site of action via the blood circulation. This is typically necessary when a drug is not absorbed well in the gastrointestinal (GI) tract, or when the patient cannot take oral medication due to their condition. For instance, parenteral routes such as intravenous (IV) or intramuscular (IM) injections are often utilized in this circumstance, particularly in healthcare settings. Chemotherapy drugs, as one example, are frequently administered directly into the bloodstream to ensure they reach the intended target effectively.
It is also worth noting that the systemic circulation is indeed part of the cardiovascular system that carries blood between the heart and the rest of the body, as opposed to the pulmonary circulation, which is the part of the cardiovascular system that carries blood between the heart and the lungs.
Routes of administration are crucial in drug therapy, with oral administration being preferred for its convenience, especially for home use. However, IV administration results in substantially higher plasma levels of most drugs than oral or IM administration, an important consideration when treating certain infections or conditions.