Final answer:
Prokaryotic microbes have internal structures that lack membranes. They lack a nucleus and other organelles with membranes, but have a nucleoid region and often a cell wall.
Step-by-step explanation:
The majority of prokaryotic microbes have internal structures that lack membranes. Prokaryotic cells are unicellular organisms that lack a nucleus and other organelles with membranes, such as mitochondria or chloroplasts. Instead, they have a nucleoid region where their DNA is located and often have a cell wall outside the plasma membrane.