Final answer:
True, a potential difference between a cell's inner and outer membrane surfaces exists, with the inner surface being negative relative to the outer surface due to ion distribution.
Step-by-step explanation:
True. A potential difference does exist between the inner and outer surfaces of the membrane of a cell. The inner surface is negative relative to the outer surface. This potential difference, typically about -70 mV to -90 mV, is created by the active transport of ions, with more negatively charged ions inside the cell and more positively charged sodium ions (Na+) outside in most cells, and especially in nerve and muscle cells. When a nerve cell is stimulated, Na+ ions flow into the cell, reversing the membrane potential, which is a key part of the nerve signal.