Final answer:
When a family inquires about a hospitalized client who has requested privacy, the nurse should maintain the client's confidentiality and kindly inform the family of their obligation not to disclose information without the patient's consent.
Step-by-step explanation:
The nurse's best response to a family inquiring about a hospitalized client who has expressed a desire for privacy is to respect the client's confidentiality. This is in line with legal and ethical guidelines that protect patient privacy, such as the Health Insurance Portability and Accountability Act (HIPAA). The nurse should inform the family that they are bound by confidentiality and cannot disclose any information without the patient's consent. It is important to be both professional and compassionate when communicating with family members, ensuring that they understand the obligation to protect the patient's privacy while also acknowledging their concern for their loved one's well-being.