Final answer:
The correct way to speak the aircraft call sign N169US is 'November one six niner uniform sierra', following the aviation phonetic alphabet.
Step-by-step explanation:
The aircraft call sign N169US will be spoken in this way: November one six niner uniform sierra. In aviation, each letter of the alphabet is assigned a corresponding word to prevent confusion over radio transmissions. When speaking call signs, each letter is pronounced as its phonetic counterpart, with numbers spoken individually, unless they form a standard number such as 100 or 1000 which are said as 'one hundred' or 'one thousand'. Therefore, 'N' is 'November', '1' is 'one', '6' is 'six', '9' is 'niner', 'U' is 'uniform', and 'S' is 'sierra', making the correct pronunciation 'November one six niner uniform sierra'.