Final answer:
The Beyond-Use Dates (BUD) for nonsterile compounded preparations are as follows: nonaqueous formulations up to 6 months or the earliest API expiration date, aqueous oral formulations up to 14 days when refrigerated, and aqueous topical and mucosal liquids and semisolids up to 30 days.
Step-by-step explanation:
The concept of Beyond-Use Date (BUD) is crucial in pharmacy practice, especially when it comes to compounding nonsterile pharmaceuticals. The BUD indicates the date after which a compounded preparation is not to be used and is determined by the pharmacist through various guidelines and studies. It is important in maintaining the safety and effectiveness of compounded medications.
According to the United States Pharmacopeia USP guidelines, the BUD for nonaqueous formulations is not later than the time remaining until the earliest expiration date of any API or 6 months, whichever is earlier. For aqueous oral formulations, the BUD is 14 days when stored at controlled cold temperatures. Aqueous topical and mucosal liquids and semisolids have a BUD of 30 days.
Please note that these guidelines are subject to change, and it is always recommended to refer to the latest USP guidelines and standards as well as any pertinent state pharmacy laws.