Final answer:
Schedule III-V prescriptions can be refilled up to five times within a six-month period before a new prescription from a practitioner is required.
Step-by-step explanation:
Schedule III-V prescriptions, according to the United States Controlled Substances Act, may not be refilled more than five times within a six-month period after the date of issue before they must be renewed by the practitioner. After this period, the practitioner needs to assess whether the patient should continue on the medication and if so, a new prescription is required. It is essential for both patients and pharmacists to adhere to this regulation to ensure proper medication management and legal compliance.