Final answer:
The maximum allowable limits for Codeine as a Schedule III substance depend on its formulation and the amount of Codeine per dosage unit. Schedule III classification requires a lower potential for abuse than Schedule I or II, accepted medical use, and the possibility of moderate to low physical or high psychological dependence. Codeine's potential for abuse and adverse effects necessitates tight regulation.
Step-by-step explanation:
The maximum allowable limits for Codeine to be classified as a Schedule III substance are not explicitly provided in the question; however, the classification of a substance under the Controlled Substances Act is based on factors such as its potential for abuse, current accepted medical use, and safety or dependence liability. For a substance to be classified as Schedule III, it must have a lower potential for abuse compared to Schedule I and II substances, a currently accepted medical use in treatment in the United States, and the abuse may lead to moderate or low physical dependence or high psychological dependence. In the United States, Codeine preparations must be limited in amount of codeine per dosage unit and combined with other non-narcotic medicinal ingredients to be classified as Schedule III.
Codeine is an opioid with relatively low potency but it does have abuse potential, requiring careful control and prescription practices. Misuse of codeine can lead to severe adverse effects, and there have been cases of accidental overdoses and other well-documented adverse reactions, especially when involved with pediatric use.