Final answer:
Proventil does not require a Patient Package Insert (PPI) each time it is dispensed, unlike Accutane and Premarin which do require PPIs due to their potential risks.
Step-by-step explanation:
The medication that does NOT require a Patient Package Insert (PPI) each time it is dispensed from the options provided is Proventil (albuterol). The PPI is a document provided with certain prescription medications to give patients important safety information about the drug, its use, and its risks. Accutane (isotretinoin) requires an iPledge program brochure which serves a similar purpose to a PPI because of its high risk, particularly in causing birth defects. Premarin (conjugated estrogens) is a hormone replacement therapy that also comes with a PPI due to risks associated with hormone treatments. However, Proventil does not typically come with a PPI; instead, it usually comes with an instruction sheet on how to use the inhaler properly. The PPI requirement is based on the medication’s potential risks and need for informed consent rather than its method of administration.