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T/F: during rearrangement of alpha:beta TCRs, unproductive rearragement between Valpha and Jalpha can be rescued by second rearrangement between upstream Valpha and downstream Jalpha segments

1 Answer

6 votes

Final answer:

Unproductive rearrangement between Valpha and Jalpha segments cannot be rescued by a second rearrangement.

Step-by-step explanation:

During the rearrangement of alpha:beta TCRs, unproductive rearrangement between Valpha and Jalpha can not be rescued by a second rearrangement between upstream Valpha and downstream Jalpha segments.

The rearrangement of the TCR genes is random and cannot be corrected if it results in an unproductive rearrangement. The T cells that undergo these unproductive rearrangements are usually eliminated through negative selection during their development in the thymus.

User Flamenco
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