84.3k views
5 votes
in Peyer's patches of gut epithelium and lymphoid tissues that line mucosa, predominant isotype switch is __

User Mikepenz
by
7.9k points

1 Answer

5 votes

Final answer:

The predominant isotype switch in Peyer's patches is to IgA, which is critical for mucosal immunity in the gut.

Step-by-step explanation:

In Peyer's patches of gut epithelium and lymphoid tissues that line mucosa, the predominant isotype switch is to IgA. These patches play a crucial role in the immune system by sampling potential pathogens from the intestinal lumen through specialized cells called microfold or M cells. The pathogens are then presented to lymphocytes within the Peyer's patches, leading to the activation of B cells, which undergo isotype switching and produce IgA antibodies. These antibodies are essential as they are secreted into the intestinal lumen, providing a primary defense against ingested pathogens by neutralizing them and preventing their attachment and entry into the body's tissues.

User Shaz
by
7.9k points
Welcome to QAmmunity.org, where you can ask questions and receive answers from other members of our community.