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in lymph nodes and spleen, where adaptive immune responses to infections in tissues and blood are made, predominant isotype switch is from ___

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Final answer:

The predominant isotype switch in lymph nodes and spleen during adaptive immune responses to infections in tissues and blood is from IgM to IgG.

Step-by-step explanation:

The predominant isotype switch in lymph nodes and spleen during adaptive immune responses to infections in tissues and blood is from IgM to IgG.

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