Final answer:
The accumulation of misfolded proteins in the ER signals the cell to produce more ER membrane and ER proteins.
Step-by-step explanation:
In the unfolded protein response, the accumulation of misfolded proteins in the ER serves as a signal for the cell to do D. Produce more ER membrane and ER proteins. When misfolded proteins accumulate in the ER, it triggers a protective mechanism called the unfolded protein response (UPR). The UPR leads to an increased production of ER membrane and ER proteins, which helps the cell cope with the stress caused by the accumulation of misfolded proteins.