Final answer:
The kinetochore, located on the centromere, is the attachment point for spindle microtubules during the M-Phase of mitosis, making the correct answer both the centromere and the kinetochore.
Step-by-step explanation:
The structural component of a eukaryotic chromosome that serves as the attachment point for spindle microtubules during M-Phase is the kinetochore, which is located on the centromere. During late prophase, also known as prometaphase, the nuclear membrane disintegrates, and spindle microtubules, extending from the centrosomes, attach to the kinetochores of the sister chromatids. This process is essential for the segregation of sister chromatids to opposite poles of the cell during mitosis. Therefore, the correct answer is e. Both a and b.