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in B cells, transport of Ig to membrane dependent on association with 2 invariant proteins, (Ig alpha and Ig beta); which provides this function for TCR in T cells?

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Final answer:

In T cells, the equivalent of Ig alpha and Ig beta in B cells is the CD3 complex and the Ζ (zeta) chain, which are responsible for the transport and function of the T cell receptor (TCR).

Step-by-step explanation:

In B cells, the transport of Immunoglobulin (Ig) to the membrane is dependent on the association with two invariant proteins, Ig alpha and Ig beta. In the case of T cells, similar to B cells, the T cell receptor (TCR) also associates with invariant proteins, which are termed CD3 complexes and the Ζ (zeta) chain. The TCR itself is composed of two different chains, typically an alpha and a beta chain, and it is these chains that are responsible for the antigen recognition, although there is also a gamma delta variant. The TCR is involved in recognizing peptides presented by Major Histocompatibility Complex (MHC) molecules.

The CD3 complex and Ζ (zeta) chain play a key role in the signal transduction of the T cell following antigen recognition. This allows T cells to become activated and carry out their effector functions. The CD3 complex consists of multiple chains, specifically CD3 gamma, CD3 delta, CD3 epsilon, and the Ζ chains, which each TCR complex contains two of. Thus, in summary, the CD3 complex along with the Ζ chain mirrors the function of Ig alpha and Ig beta in B cells, providing TCR assembly and transport to the cell membrane, as well as transducing activation signals upon antigen recognition.

User Mathew Thompson
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