Question

. The low pH inside endosomes:

A. destroys internalized cargo proteins.
B. destroy internalized receptors.
C. causes internalized receptors to release their cargo.
D. causes cargo proteins to bind to their receptors.

Answer 1

The low pH inside endosomes causes internalized receptors to release their cargo.

Step-by-step explanation:

The low pH inside endosomes causes internalized receptors to release their cargo. Once internalized, the coated vesicles lose their clathrin and associated adaptor protein coat. The uncoated vesicle fuses with an early endosome to form a sorting vesicle (i.e., late endosome).

Sorting vesicles separate imported content from the receptors that are recycled to the membrane. In the vesicle that remains, now a lysosome, digestive enzymes catalyze hydrolysis of the vesicle contents. The digest products are then released for cellular use.