Final answer:
Prokaryotes have a circular chromosome, while eukaryotes have multiple linear chromosomes. Eukaryotes use histone proteins to package their DNA, unlike prokaryotes. Prokaryotes lack a nucleus to maintain their DNA, whereas eukaryotes have a nucleus.
Step-by-step explanation:
Prokaryotes have a single, circular chromosome, while eukaryotes have multiple, linear chromosomes. Eukaryotes pack their chromosomes by super coiling, managed by DNA gyrase.
Prokaryotes chromosomes are wrapped around histone proteins that could form heterochromatin, which is not present in eukaryotes.